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Superoxide radical anion, hydroperoxyl, and thiyl radicals The superoxide radical is considered a primary ROS produced in mitochondria by electron leakage from the electron transport chain to molecular oxygen in the course of oxidative phosphorylation (Valko et al

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J Agric Food Chem 61:269277 Kumar C, Sharma R, Bachhawat AK (2003) Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae : evidence for an alternative glutathione degradation pathway

Its activation triggers the HPA axis, which is controlled, among other mechanisms, by the GR

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