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Glial cells play an important role in both LPS disruption of the BBB and the development of SAE after BBB disruption (Haruwaka et al., 2019

This usually resolves within a few days as your skin adjusts

Stress Chaperones 28 (6), 709720

However, these compounds have thus far not had been subjected to clinical trials, possibly because of unwanted side effects, including lower Ca 2+ transport or increased heme-oxygenase (HO-1) levels (Konorev et al., 2002)