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When abnormal results are detected, the interpretation should include an overview of the results and their significance, quantitative results with age-appropriate reference ranges, a correlation to available clinical information, elements of differential diagnosis, recommendations for additional biochemical testing and in vitro confirmatory studies (e.g., enzymatic analysis, molecular analysis), and a phone number to reach the reporting laboratory with additional questions

It was these findings that paved the way for the use of mTOR inhibitors as potential therapies for mitochondrial disease (Johnson et al., 2013

Free Radic Biol Med (2018) 125:3643

van Vliet, A

A random search strategy with up to 1,000 evaluations was employed within each learner-specific parameter space, using AUC as the optimization criterion