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Patients who can tolerate gastrointestinal side effects during the initial titration period typically achieve substantial long-term weight loss

Patients starting semaglutide are often already on metformin or proton pump inhibitors (which block tablet absorption)

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doi:10.1201/9781315119540

Reduced Fatigue and Increased Motivation : Many individuals on weight loss or fitness journeys struggle with fatigue, which can hinder progress