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Figure 2 ME/CFS severity classifications The long-term outlook for ME/CFS patients varies significantly (32), lung disease (33), rheumatoid arthritis (RA) (3335), and some forms of cancer (33, 35)

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NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics

During cerebral ischemia or hypoxia, the deprivation of energy and the consequent increase in the AMP/ATP ratio facilitates AMPK phosphorylation and initiates autophagy to bolster energy production (Jiang et al., 2014