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* Correspondence: Lin Lu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Furthermore, degenerating neurons release intrinsic pro-inflammatory active components, triggering a harmful feedforward loop that elicits microglial responses, leading to a progressively worsening immune reaction (Fuzzati-Armentero et al., 2019)

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