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Furthermore, substantial evidence suggests that IR may precede NAFLD

However, the GAr domain of the EBNA-1 limits antigen presentation by reducing translation and proteasomal processing by MHC-I ( + T-cells, typically involved in antigen recognition and presentation by MHC-I ( + T-cells are primed to EBNA-1 ( + T-cells in healthy individuals can recognize autologous EBV-transformed B-lymphoblastoid cell lines (B-LCL) and kill EBNA-1-expressing targets through CD95L/CD95-mediated pathway ( + T-cells have been found to expand selectively and cross-recognize MS-associated MBP, leading to MS pathology ( + T-cells against a specific sequence of EBNA-1 ( Although most T-cells normally react to one specific antigen, studies in MS and long-term EBV carriers have shown that a high proportion of EBV-specific CD4 + and CD8 + T-cells are polyfunctional cells (PFCs) ( - CD4 + T-cells producing IFN-, MIP1-, TNF-, and IL-2