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Hepatotoxicity of ketoconazole in Sprague-Dawley rats: glutathione depletion, flavin-containing monooxygenases-mediated bioactivation and hepatic covalent binding

112 Unfortunately, in this and a few other case reports of severe secondary oxalosis, no details were provided regarding the potential presence of a loss-of-function mutation in genes involved in primary hyperoxaluria in these patients

Other obvious muscarinic effects include severe lacrimation and profuse sweating, followed by nausea and vomiting, along with dyspnea and shortness of breath due to bronchorrhea and bronchoconstriction