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Further, HS lowers thyroid hormones (T3 and T4) synthesis by affecting the hypothalamic-pituitary axis 12

These ranges are typically well-tolerated and effective for raising systemic levels over several weeks

Increase in clinical symptoms 3

doi:10.1016/j.ejpain.2006.08.004 [DOI] [PubMed] [Google Scholar] 56.Johannes CB, Le TK, Zhou X, Johnston JA, Dworkin RH

h-HepOrgs mimic liver structure and function To characterize the expanded h-HepOrgs, we first performed RNA sequencing (RNA-seq) analysis on early (passages 13) and late (passage 10) cultures and compared their expression patterns with those of freshly isolated primary human hepatocytes (PHHs) and h-CholOrgs from the same donors (when possible)