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Nutrients 15(7):1773 Hu X-J (2019) Protective capability of Astragalus (Huangqi) on auditory function in a rat model of estrogen deficiency

To better understand the pharmacokinetics of UDE and its potential to enhance intracellular GSH levels, it is important to conduct in vivo trials that involve administering different doses of UDE at various time intervals

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Indeed, insulin-stimulated phosphorylation of multiple TBC1D4 phosphosites was impaired in insulin-resistant muscle from diabetic or TNF-infused patients [99,100], and conversely, exercise-induced phosphorylation of TBC1D4 S711 was required for improved insulin action in mice [101,102]

Thus, the results from these studies cannot be generalized until robust RCTs are available