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4I), and further increased the tumoral MDSC population exclusively in the GPX4 knockdown tumors (Fig

Cortez AJ, Tudrej P, Kujawa KA, Lisowska KM

Chen H, Tan XN, Hu S et al (2021) Molecular mechanisms of chondrocyte proliferation and differentiation

This interaction not only antagonizes Kyn-induced AhR activation but also suppresses the expression of indoleamine 2,3-dioxygenase (IDO)1a key enzyme driving Trp catabolism to Kynand subsequent differentiation of Tregs, thereby reversing the immunosuppressive TME (112, 161)