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Key studies demonstrate their ability to penetrate the blood-brain barrier (BBB) ( Due to their minuscule size, MPs and NPs are hypothesized to traverse biological barriers, including the blood-brain barrier, infiltrate cellular interiors, and potentially exert direct cytotoxic effects (Wu et al., 2023)

In addition, the peptide supports structurefunction and peptide-engineering studies , where researchers evaluate how specific amino-acid motifs influence biological pathway outcomes

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Consequently, inhibition of ACSL4 or LPCAT3 reduces these oxidizable phospholipid-polyunsaturated fatty acids (PL-PUFAs), rendering cells resistant to ferroptosis (74, 75)

Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926