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It has been extensively studied in preclinical models for its effects on tissue healing and cytoprotection

Although evidence linking low folate levels to ALS remains inconsistent, oral vitamin B12 supplementation can significantly elevate plasma folate and B12 levels while reducing Hcy in ALS patients [189]

Hohenblum H, Borth N, Mattanovich D

Studies indicate that AOD-9604 increases the expression of beta-3 adrenergic receptors in tissues, though the compounds effects are not directly mediated through these receptors