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In an open uncontrolled trial, 32 IC/BPS patients were treated with 400 mg micronized PEA plus 40 mg polydatin (a naturally occurring precursor to the polyphenol resveratrol) twice daily for three months followed by once daily for three months

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Excretion Pathways Limited characterization of excretion routes indicates: Renal elimination likely for peptide fragments following proteolytic degradation No detection of intact peptide in urine following single-dose administration No evidence of bioaccumulation in chronic dosing studies (rat models) Hepatic metabolism may contribute to peptide fragment processing The rapid elimination kinetics combined with prolonged pharmacodynamic effects represent a unique aspect requiring further investigation to fully characterize Selanks pharmacological profile

Archived from the original on August 19, 2016

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