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Thus, tau hyper-phosphorylation is another neuropathologic hallmark of AD and is linked to microglia activation and neuronal damage (Medeiros et al., 2010

The Phase I trial will study target dose levels of 5 mg/kg, 10 mg/kg and 20 mg/kg of PGN-EDODM1, with safety, transcript splicing and clinical outcome measures data from the 5 mg/kg cohort expected in 2024