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however, it is well-known for causing hemorrhagic cystitis (HC)

Glu, which is synthesized in neurons and is the major excitatory neurotransmitter in CNS, had similar temporal changes to NAA in the injured hippocampus

3.2.2 Initial serological tests should include anti-nuclear, anti-smooth muscle, and anti-liver kidney microsomal type-1 antibodies (LOE 3, Strong recommendation)

The condition worsens when the patient has stage 3 AKI and requires RRT, particularly CRRT

Future challenges to overcome in the development of NRF2 activators as disease modifying treatments include the establishment of compounds with good pharmacokinetic and pharmacodynamic profiles that ensure sustained, brain wide NRF2 activation