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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

and (iii) by oxidative cleavage of the peptide backbone via the -amidation pathway or via oxidation of glutamyl side chains (Berlett and Stadtman 1997

During Phase 1, detoxification, toxins from car exhaust, smoke, alcohol, caffeine, dioxin, drugs, radiation, heavy metals, pesticides, and other carcinogens are partially processed by specialized proteins inside mitochondria cytochromes

Ephedrine acts partly directly on the receptors but mainly by releasing endogenous noradrenaline, which in turn affects the receptors

thus it seems highly likely that these processes occur in konzo, a motor neuron disease triggered in part by the consumption of toxic compounds that are well established to increase oxidative stress 43