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Oxidative stress throws a wide net in terms of the types of macromolecules and organelles it threatens including proteins, fats, DNA, and even mitochondria

Oxidative stress involved in the pathogenesis of COPD is not only the result of the increased burden of oxidants but also owing to a decrease in antioxidative potential [38]

171 In insulin resistance, elevated leptin levels reflect central leptin resistance, disrupting energy homeostasis and promoting hyperglycemia

Moreover, in a meta-analysis that included five studies focusing on type 2 diabetic patients, the alanine-encoding allele was associated with a reduced risk of macroalbuminuria (CR 0.65, 95% CI 0.520.80) compared with the valine-encoding allele (Tian et al., 2011)

doi: 10.3390/nu11061356 71