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Methods: In this phase 3 multicenter, randomized, double-blind, placebo-controlled study, subjects were randomized 1:1:1 to receive once-daily oral placebo, OCA 10 mg, or OCA 25 mg

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2016 Aug 1;73(8):78995

Understanding quality of life issues in patients with advanced melanoma: phase 1 and 2 in the development of the EORTC advanced melanoma module

Deficient GLYR1 also partially rescues the phenotypes of the photorespiratory mutant cat2 , but not those of plgg1 To investigate if the partial suppression of hpr1 by glyr1 is specifically linked to HPR1 or broadly connected to components of the photorespiratory pathway, we crossed glyr1-1 into two other photorespiratory mutants, cat2-1 and plgg1-1 , which are defective in the peroxisomal catalase 2 enzyme and the chloroplast glycolate/glycerate transporter, respectively (Fig