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To a stirred solution of 3-(3-(difluoromethoxy)phenyl)-4,4-difluoro-1-(tetrahydro-2H-pyran-4-yl)-4,5,6,7-tetrahydro-TH-indazole-6-carboxylic acid (55.6 mg, 0.13 mmol) in DMF (0.6 mL) was added DIPEA (0.11 mL, 0.65 mmol), HATU (59.2 mg, 0.16 mmol), and 3-amino-3-methyltetrahydrothiophene 1,1-dioxide (23.2 mg, 0.16 mmol)

Did any serious adverse events occur with AOD-9604

Data Availability Statement All data that support the findings of this study are available from the corresponding author upon reasonable request

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Cancer risk in cystic fibrosis: a 20-year nationwide study from the United States