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It is likely that zonulin release is initiated by dysbiosis and gliadin by a similar mechanism

A single-copy gene, 36B4, was used as a genomic DNA control and copy number determination

This novel strategy combining manipulation of enzymatic crosslinkers using exogenous LOXL2 supplementation appears to be a promising technique for engineering more physiologically relevant cartilage constructs (Kwon et al ., 2019)

Endogenous stimuli from the microenvironment The tissue microenvironment has significant characteristics in some special diseases like diabetes, and pathological changes such as changes in or the appearance of pH, ROS, and specific enzymes, occur in the microenvironment