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Natural Products Natural products, including alkaloids, polyphenols, and flavonoids, exhibit various biological activities, such as anti-inflammatory, antitumor, and anti-oxidative stress effects, providing highly valuable lead compounds for new drug research and development

doi: 10.3390/antiox9030236

Ovarian cells were found to secrete significant levels of VEGF, a direct activator of angiogenesis, but squalamine did not reduce VEGF secretion by tumor cells, and it evoked no direct growth inhibition of ovarian cells in vitro [69]