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J Clin Invest 40:981988

What is the safe upper intake level of folic acid for the nervous system

Until recently, the published studies with the new obesity pharmacotherapies have had up to 2 years follow-up [12]

Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses

It has been studied in preclinical and exploratory clinical settings for roles in wound repair, skin regeneration, hair biology, and extracellular-matrix (ECM) remodeling