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TCB II: 4247kDa protein Essential protein in the delivery of vitamin B12 to cells and tissues The production site of TCB II is primarily hepatocytic, and secondarily endothelial, monocytic and intestinal Functions of vitamin B12: B12 acts as a cofactor for two key enzymatic reactions: Methionine Synthase (cytoplasm): Converts homocysteine methionine Requires methylcobalamin Supports DNA synthesis via the folate cycle (regenerates tetrahydrofolate) Methylmalonyl-CoA Mutase (mitochondria): Converts methylmalonyl-CoA succinyl-CoA Requires adenosylcobalamin Involved in fatty acid and amino acid metabolism Elevated vitamin B12 (hypervitaminemia B12) While vitamin B12 deficiency is commonly discussed, elevated serum B12 (hypercobalaminemia) is less common and often overlooked or misinterpreted

Abbas Z, Rehman S

Instead, the researchers were also unsure why the gap closed after an additional four weeks of study, but offered the explanations that the different groups may not have been eating enough to get the full benefit of their training, or, conversely, had overtrained

No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately

An additional secondary endpoint was 6MWD at Months 6 and 12