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Mitochondrial Function ATP Production by Oxidative Phosphorylation Mitochondria is the metabolic center of cellular activities

Gene Modification Therapy Approximately 20 causative genes are associated with familial PD, while over 200 genes have been implicated in sporadic PD

Included studies comprised original research publications in English and reference lists from review articles

Recent studies with animal models provide evidence that pheomelanin pigment pathway is implicated in UV radiation-independent carcinogenic contributions to melanomagenesis by mechanisms of oxidative damage 6,7,8 Two non-exclusive hypotheses were proposed to define pheomelanins pro-oxidant activity: (i) the pigment promotes the formation of damaging ROS and (ii) the pigment depletes protective antioxidants (e.g., glutathione) 9,10

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