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Another thing to consider is wich brand of hydroxycobalamin you use

If you are suffering from extreme fatigue, lethargy, muscle weakness, pins and needles, mouth sores, or cognitive problems including irritability, depression, or lapses in memory, it may be a sign that you are deficient in Vitamin B12 and could benefit from regular supplementation with Vitamin B12 booster injections

When stored under recommended conditions, the lyophilized form stays stable for lab use and long-term storage