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For whole-body analysis, a biological replicate containing four nurse or forager bees, which were ground separately in liquid nitrogen prior to RNA extraction

Rather than functioning as isolated antidepressant agents, these botanicals target complementary nodes within the interconnected pathophysiology of depressive disorders, encompassing monoaminergic dysregulation, impaired neurotrophic signaling, HPA-axis hyperactivity, neuroinflammation, oxidative stress, and mitochondrial dysfunction

The therapeutic benefits of curcumin for these neurodegenerative diseases appear multifactorial via regulation of transcription factors, cytokines and enzymes associated with (Nuclear factor kappa beta) NFB activity

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