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However, they can cause a wide range of side effects, such as allergic reactions, osteoporosis, bone marrow suppression, and serious hepatic damages.[1,2] Considering the complications caused by drugs used in patients with UC and also the available evidences that show the protective effects of some food components against the inflammation associated with colitis, finding of alternative or complementary treatments, such as consuming dietary supplements, vitamins, nutrients, and probiotics, is assumed to be effective and safe in the management of colitis.[3,5] Vitamin B1 is a water-soluble vitamin and is absorbed in the ileum and jejunum by active and passive uptake.[5] Symptoms of thiamin deficiency mainly include fatigue, loss of appetite, constipation, digestive disorders, cramps, and muscular atrophy.[6] The analgesic and anti-inflammatory potential of thiamin has been investigated in one study and has shown remarkable effects in high doses.[7] The role of riboflavin (vitamin B2) in the proper functioning of the immune system and its deficiency in inflammatory diseases has been investigated in several studies.[8,9] It has been shown that the oral consumption of riboflavin in rats is capable of creating an anti-inflammatory and anti-hyperalgesia effect against painful inflammatory stimuli.[10] Vitamin B6 exists in three forms, among which pyridoxal 5- phosphate (PLP) is the most biologically active compound

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