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A common protocol involves administering 1,000 mcg of B12 weekly for 4 to 8 weeks, depending on the deficiencys severity and the patients response

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[DOI] [PMC free article] [PubMed] [Google Scholar] 294.Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES

The mRNA expression studies done at that time provided strongly elevated (nitric oxide synthase 2) and decreased (cyclooxygenase-2, vascular endothelial growth factor A, nitric oxide synthase (NOS)-1, NOS-3, nuclear factor-kappa-B-activating protein) gene expression