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This can lead to increased levels of oxidative stress and inflammation, eventually contributing to the death of neural cells

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Butyrate appears to be the most important SCFA to regulate tight junction proteins and has been shown to improve intestinal barrier function by increasing claudin-2 through the activation of AMPK (Caetano and Castelucci, 2022)

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56 Loss of hepatic metabolic function lead to hypoglycemia, lactic acidosis and hyperammonemia