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These effects involve the activation of brain CRF receptors (Tach and Bonaz, 2007)

Notably, injection site discomfort with GHK-Cu tends to be more frequent than with other peptides, due to the copper component

Reported tolerability in the available human observational work is high: no consistent pattern of adverse effects has been published, although the absence of placebo-controlled trials means subtle effects cannot be excluded

In contrast, nanomaterials can well compensate for these difficulties because of their unique advantages, among which, nanoformulations with tumor microenvironment responsiveness have good prospects for application