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Application of glutathione depletion in cancer therapy: Enhanced ROS based therapy, ferroptosis, and chemotherapy ScienceDirect Frontiers Radiation induced skin injury: a review of pathophysiology, assessment, management, and re irradiation protocols Excessive glutathione intake contributes to chemotherapy resistance in breast cancer: a propensity score matching analysis World Journal of Surgical Oncology Springer Nature Link Glutathione IV Therapy: Timeline for Skin Lightening Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy PMC

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In a different study done n the Indian population with Melasma consisting of 312 patients, the female to male ratio was much lower, i.e., 4:1

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Exp Toxicol Pathol 64:549556 Sancheti H, Akopian G, Yin F, Brinton RD, Walsh JP, Cadenas E (2013) Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimers disease

Further, the mice treated with IMQ to elicit psoriasis-like signs showed a boost in the thickness of the skin, an augmentation of the spinous level, and extensive inflammation in their histology