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A key implication of T cells in long COVID, compatible with virus persistence, could be demonstrated by whole-body positron emission tomography imaging with a selective tracer that allows for anatomical quantitation of activated T lymphocytes ( In inflammation and autoimmune processes, T cells, B cells (and the antibodies that they produce) and inflammatory monocytes/macrophages may form a cellular network acting in a pathogenic way
10.1039/d0nr03698f 48 GujratiV.PrakashJ.Malekzadeh-NajafabadiJ.StielA.KlemmU.MettenleiterG.et al (2019)
The amount of folate given is quickly depleted by rapidly dividing (cancer) cells, so this does not negate the effects of methotrexate
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