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5-Amino-1MQ Animal Studies Studies using 5-Amino-1MQ specifically have demonstrated its potency and selectivity as an NNMT inhibitor, with IC50 values in the low micromolar range and good selectivity over other methyltransferases

While the HLA region is the most significant genetic risk factor, a multitude of other genes also contribute to T1D susceptibility

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Studies on mice lacking ANXA2 showed that this transport system is important for normal fat tissue development

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