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The mitochondrial outer membrane permeabilization increases and cytochrome C is released into the cytoplasm [19]

Sebastian M, et al

Importantly, when astrocytes are exposed to inflammatory stimuli (e.g., TNF-/IL-1/C1q), the HK2PINK1 axis becomes up-regulated, enhancing mitophagy and reducing neurotoxic outcomes in neuronastrocyte co-culture models and in vivo

Gene knockout, gene silencing, and other technologies, such as the CRISPR/Cas9 system or RNA interference, can be employed in cells or animal models to specifically knock out or reduce the expression of the target gene