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In the ovariectomized rat, single IV doses of zoledronic acid of 4-500 mcg/kg (0.1 to 3.5 times the human 5 mg intravenous dose, based on body surface area, mg/m2) suppressed bone turnover and protected against trabecular bone loss, cortical thinning and the reduction in vertebral and femoral bone strength in a dose-dependent manner

After administration, pyridoxine is converted in the body to its active metabolite, pyridoxal 5-phosphate (PLP), by the enzyme pyridoxal kinase

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