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Journal of Allergy and Clinical Immunology

& Munthali, R

Introduction Proton pump inhibitors (PPIs) are currently the most widely used acid-suppressive agents and are the first-line therapy for gastric acidrelated disorders, such as peptic ulcer disease, gastroesophageal reflux disease (GERD), and Barretts esophagus ( + , K + ATPase activity in epithelial cells to prevent gastric acid secretion (Sachs et al., 2006