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There are no adequate and well-controlled studies on pregnant women

In an initial longitudinal study of severely ill CAD patients who had collectively sustained 49 cardiac events in the 8 years before enrollment, adherent patients achieved a mean total cholesterol reduction from approximately 246 mg/dL to 137 mg/dL, and none experienced a recurrent cardiac event over the 12-year follow-up

Ding Y, Zhang H, Liu Z, Li Q, Guo Y, Chen Y, et al

Three quarters of patients managed with pasireotide require other medication for glucose management

ELAVL1 silencing demobilized both GAC (from 1.74 to 1.22) and KGA (2.07 to 1.71) from polysome to monosome fraction, implying a reduction on translation of both isoforms