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Acute striatal necrosis can be divided into three stages [70].The first stage is cytotoxic edema in the basal ganglia, cerebral ischemia, and increased blood volume in the gray matter, which occurs within 24 h after motor deficits, and cranial MRI shows increased signal intensity on T2-weighted imaging of the shell nucleus and caudate nucleus [71], along with diffusion limitation [72]

Reducing acne-causing bacteria Accutane also reduces the number of Cutibacterium acne, which can contribute to acne production in the skin