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Kamada K, Goto S, Okunaga T, Ihara Y, Tsuji K, Kawai Y et al

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Estrogen may act as a powerful stimulator of autoimmunity while male hormones play a protective role

130,131 Most studies indicate that IDH2 is also significantly upregulated in ESCC, 132 ovarian cancer, 133 lung cancer and other types of cancer, 134 playing a pro-oncogenic role