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Cardiovascular events Several randomized, placebo-controlled, multicenter trials have investigated the efficacy and safety of nicotinic acid therapy, alone or in combination with other lipid-lowering agents, on outcomes of cardiovascular disease (CVD)

In patients in the placebo-controlled studies of STS 6 mg/24 hours, the only adverse event with an incidence of twice that of the placebo group was application site reaction.55 In higher-dose studies (9 mg/24 hours or 12 mg/24 hours), adverse events with an incidence of at least twice that of placebo included insomnia (32% vs 7%), dry mouth (13% vs 6%), dizziness (14% vs 5%), nervousness (10% vs 4%), and abnormal dreams (5% vs 2%).55 Most adverse events were considered mild or moderate

Following intracerebroventricular administration of various doses of 0.1, 0.3, 1, 3, and 10 nmol/L, TWL significantly increased compared to saline controls

This can include water flavored with fruits or vegetables (lemons, berries, orange or cucumber slices), or from coffee or tea