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Although the final analysis and current expert consensus guidelines suggest that such patients may not require stem cell therapy, this conclusion remains open to challenge given the limited sample size

The tripeptide Gly-His-Lys binds copper in a chelated form that's highly susceptible to oxidative degradation once mixed with bacteriostatic water

A phase 2 trial of mexiletine, a sodium channel blocker, demonstrated dose-dependent reduction in muscle cramps, though 300 mg doses were associated with fewer adverse events

2022;45:S1S2

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy