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Altogether, these studies including ours using 1.7~1.8 GHz RF-EMF strongly suggest that the increased ROS generated by RF-EMF induce physiological changes in various mammalian cells, although the physiological outcome would be varied depending on the amount of ROS generated and the sensitivity of different cell types to the specific concentration of ROS

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On the other hand, the accumulation of AGEs can bind to RAGE in kidney cells, which further leads to the intracellular inflammation and oxidative stress signaling pathways, such as nuclear factor-B (NF-B), phosphatidylinositide 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), etc