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Each experiment was independently repeated three times and data is presented as mean plus or minus standard deviation unless otherwise noted

Genomic epidemiology methods further suggest a potential link between the increasing clinical incidence of azole-resistant IA and the increasingly widespread presence of azole-resistant genotypes in environmental isolates ( 3 Common antifungal drugs and associated resistance mechanisms Common antifungal drugs include polyenes, azoles, allylamines, morpholines, and echinocandins, all of which function as antimetabolic agents targeting essential fungal structures or biosynthetic pathways (Fisher et al., 2022

Twenty-four hours later the culture medium was replaced with the lentivirus-containing medium (lentiviral titer 110 8 TU/mL, MOI = 3) and incubated for 6 h

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The antiproliferative effects of compounds 19 and 21 were enhanced compared to CBD (with an inhibition IC 50 of 5.5, 4.1, and 22.9 M respectively