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IGF1 and IGF2 have been shown to bind to hybrid receptors with high affinity whereas human insulin binds with low affinity 9,10

doi: 10.7150/ijbs.7.645 136 JaworskaKHucTSamborowskaEDobrowolskiLBielinskaKGawlakMet al

Modeling of more detailed factors, such as the size distribution of gaps opened in the BBB, would improve the accuracy of the calculation

Despite there being various techniques to encapsulate the drugs and increase encapsulation efficiency, the freeze-thaw cycling and reverse phase evaporation techniques are used extensively [135]