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The expression and activities of GPX3 are changed in many pathological processes involved in systemic non-neoplastic disorders, such as kidney diseases, cardiovascular diseases, respiratory diseases, metabolic diseases, digestive system diseases, neurological disorders, bone and joint diseases, and other diseases (Figure 3)

have reported that low levels of frataxin leads to the reduced expression of NRF2 and antioxidants present in the dorsal root ganglia of FRDA mouse models (Shan et al., 2013)

Calculations Enzyme activities of AChE, BChE were calculated using the following equations: Activity of AChE (Units/L) = A 56520 Activity of BChE (Units/L) = A 11300

10.5137/1019-5149.JTN.11405-14.1 109 RheeS

Therefore, GPX4-mediated ferroptosis may be a promising target for treating major depressive disorder