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The gas chemically inactivates B12 through irreversible oxidation of its coenzyme form, methylcobalamin, at the active site of the B12dependent methionine synthase reaction

Kolovrat et al., 2020) and with vessels that used to be obstructed (Duzel et al., 2017

Clearly, in studies designed to establish adequate/normal serum MAA adult values, it is advisable to evaluate renal function using serum creatinine, especially in older adults