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Obesity Treatment For individuals with obesity (BMI 30) or overweight (BMI 27 with weight-related comorbidities): Standard dose: 2.4 mg weekly after titration Duration: Long-term maintenance therapy Monitoring: Regular weight, metabolic parameters, side effects The REDEFINE 1 trial specifically enrolled this population, providing robust evidence for efficacy and safety

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Summary Keywords fragment screening, trypanosomatid infection, trypanothione reductase, rational drug discovery, protein crystallography Citation Fiorillo A, Colotti G, Exertier C, Liuzzi A, Seghetti F, Salerno A, Caciolla J and Ilari A (2022) Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design