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New insights into the classification and mechanisms of hereditary, chronic, non-haemolytic hyperbilirubinaemias

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Numerous studies have demonstrated that FOCM plays essential roles in cell growth and development in higher plants and mammals, particularly in maintaining genome stability and in cell proliferation [24, 42]

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It is characterized by continued damage and progressive loss of RGCs and the retinal nerve fiber layer, as well as alterations of the optic disc and optic nerve head, eventually leading to progressive and irreversible constriction and loss of the visual field (Quigley and Broman, 2006