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2-oxoglutarate, a product of the catabolic reaction of the NADP-GDH and an intermediate of the TCA cycle, inhibits the binding of GdhR to gdhA P2 (Pagliarulo et al., 2004)

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NAFLD alleviating potential of black cumin oil has also been studied in a randomized, double-blind, placebo-controlled clinical trial, which demonstrates a reduction in FBS level, lipid profiles (TG, TC, LDL, VLDL), liver enzymes (AST and ALT), hs-CRP inflammatory marker, IL-6, TNF-, and an increase in the HDL-C levels in the interventional group compared to the placebo group [163]

The activities of SOD, CAT, and APX scavenge ROS, which otherwise cause oxidative damage, and then convert them to harmless H 2 O and O 2 (Shekhawat et al., 2010)